2/20/2023 0 Comments Levelfix 305hv![]() Our findings may have a profound impact on the management of patients presenting with acute renal colic. The NIH funded study through AHRQ has finished with >2500 prospectively enrolled patients with a 2 year follow-up our data was recently published in the New England Journal of Medicine. I have collaborated with Rebecca Smith-Bindman in our Radiology Department to determine whether CT imaging of patients presenting with renal colic could be replaced with US imaging. Patents have been issued and term sheets are in process to move this commercial product (conceived from my clinical and basic science research) forward. This drink may also be beneficial for individual with bone disease. I am collaborating with NYU and Mass General to develop a unique drink for patients to help reduce recurrent nephrolithiasis. Patents have been issued (US2013/0123781) and we are in active discussions with various companies to develop a commercial application. Proof of concept with high speed photography was performed with collaborators at the University of Washington. Injection of our specialized tagged bubbles will attach to the offending stone/s and with appropriate energy sources will cavitate and fracture the stones. In collaboration with Bob Grubbs at Caltech we are developing a new minimally invasive technique to potentially replace routine endourologic techniques to treat urinary stones. Techniques to stain and visualize these concretions continues to be in progress. We also are investigating the role of uric acid metabolism in stone development. We recently developed an additional fruit fly model that will develop cystine and calcium based stones. Presently, I have three post docs helping with this project. I recently received a R-21 and P-20 NIH funding to further these studies. ![]() I have collaborated with researchers at the Buck Institute on Aging, the Advance Light Source at the Lawrence Berkeley National Laboratory, Oakland Children’s Hospital, UC Davis, and Julian Dow in Glasgow to help mature this intriguing invertebrate fly animal model. By knocking out specific zinc transporters in our first fruit fly model we were able to demonstrate that stone development dramatically decreases. We utilized the synchrotron at the Lawrence Berkeley National Laboratories to identify non-trace amounts of zinc in Randall plaques (early human urinary stones) and in our recent Drosophila fly model. I have recently identified zinc as a critical factor in the early mineralization process. 229920001184 polypeptide Polymers 0.My clinical and research efforts continue to be centered around the treatment and understanding the pathogenesis of urinary stone disease.108010039209 Blood Coagulation Factors Proteins 0.000 title claims abstract description 720. ![]() 102000015081 Blood Coagulation Factors Human genes 0.000 title claims abstract description 720.239000003114 blood coagulation factor Substances 0.000 title claims abstract description 727. ![]() Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.) Filing date Publication date Priority to US201562182370P priority Critical Priority to US62/182,370 priority Application filed by Opko Biologics Ltd filed Critical Opko Biologics Ltd Priority to PCT/IL2016/050645 priority patent/WO2016203482A2/en Publication of AU2016280867A1 publication Critical patent/AU2016280867A1/en Application granted granted Critical Publication of AU2016280867B2 publication Critical patent/AU2016280867B2/en Status Active legal-status Critical Current Anticipated expiration legal-status Critical Links Original Assignee Opko Biologics Ltd Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.) ( en Inventor Udi Eyal Fima Gili Hart Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.) Active Application number AU2016280867A Other versions AU2016280867A1 Google Patents AU2016280867B2 - Long-acting coagulation factors and methods of producing same AU2016280867B2 - Long-acting coagulation factors and methods of producing same ![]()
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